What is Linzess/Constella (Linaclotide) used for?
Linzess (linaclotide), known as Constella outside of the U.S and Mexico, is used to treat bowel conditions such as irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). It increases the amount of fluid in the intestines, softening stool, and it allows food to pass through the body more easily. It helps to relieve uncomfortable symptoms such as unfinished bowel movements, bloating and abdominal pain. This is not recommended to give linzess to children 6 years to less than 18 years of age due to the risk of dehydration (loss of body water and salt). Do not share this medication with others as this may not treat their symptoms and can cause an adverse reaction. Consult a doctor if you are pregnant or plan to become pregnant. It is unknown if Linzess will harm the fetus or pass to breast milk.
Linzess/Constella (Linaclotide) Information
How to Use Linzess?
Your doctor should provide instructions on how to use Linzess. The manufacturer also provides a patient information leaflet for reference. If you have any additional questions, call your doctor or pharmacist. Your dose and instructions may vary depending on your condition and response to treatment.
Linzess is taken half an hour prior to your first meal on an empty stomach for at least 12 weeks of linzess treatment or longer. Do not break or chew the capsules; swallow them whole to get the medication into your system. If you cannot swallow the capsule whole, contact a doctor or pharmacist on alternative methods to take the capsules.
This has to be taken consistently to get optimal results. If you miss a dose, simply skip it and take the next one on schedule. Do not take an additional dose to “catch up”. Taking more than the recommended dose can result in more frequent or severe side effects.
What are Side Effects of Linzess?
Linzess has known side effects. This is not a complete list and includes frequently reported adverse events. Report side effects to your doctor or pharmacist if they are severe or you need help managing them.
Diarrhea, the most common side effect can be severe. If you experience severe diarrhea, stop taking linzess and call your doctor.
- loss of appetite
- pressure in the stomach
- tightness in the chest
- pain or tenderness around the eyes and cheekbones
- unusual tiredness or weakness
- vomiting
- Abdominal or stomach pain
- dizziness
- loss of voice
- Acid or sour stomach
- excess air or gas in the stomach or intestines
- sunken eyes
- lightheadedness
- stomach discomfort or upset
- ear congestion
- full or bloated feeling
- indigestion
- thirst
- stuffy or runny nose
- sore throat
- severe diarrhea
- passing gas
- headache
- increase in heart rate
- nausea
- belching
- confusion
- difficulty swallowing
- fainting
- weakness
- sneezing
- wrinkled skin
- fever
- cough
- shortness of breath
- bloody, black, or tarry stools
- Heartburn
- swelling of the abdominal or stomach area
- puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
- decreased urination
- Bleeding from the rectum
- rapid breathing
- loss of bowel control
- chills
- Body aches or pain
- dry mouth
- hives or welts, itching, or skin rash or redness
- fast heartbeat
Linzess Drug Interactions?
It is important to disclose all your current medications with your doctor to prevent allergic reactions or adverse interactions. They may have to make a decision if the interaction is worth the benefit of using either drug or if your therapeutic regime needs to be changed.
Linzess Coupons?
Current discounts and promotions for Linzess can be found here
What is the active ingredient in Constella?
The active ingredient in Constella is linaclotide. Linaclotide is a type of medication known as a guanylate cyclase-C agonist. It works by increasing the secretion of fluids in the intestines, which helps to ease bowel movements. Constella is primarily used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC).
Recommended dosage for Constella?
The recommended dosage of Constella (linaclotide) for adults with irritable bowel syndrome with constipation (IBS-C) is 290 micrograms once daily. For chronic idiopathic constipation (CIC), the recommended dose is 145 micrograms once daily. It should be taken on an empty stomach, at least 30 minutes before the first meal of the day. Always follow the doctor's instructions for proper dosing.
Constella Price in Canada
Starting price of Constella 72mcg Capsule (Known in the US as Linzess) price in Canada
- 30 caps - $184.79 USD ($6.16 per caps)
- 60 caps - $353.85 USD ($5.90 per caps)
- 90 caps - $508.19 USD ($5.65 per caps)
Linzess/Constella (Linaclotide) FAQs
How long does it take for Constella to start working?
Constella (linaclotide) typically starts working within 1 to 2 weeks of regular use. However, some people may notice an improvement in their symptoms sooner, while for others, it may take a little longer. It’s important to continue taking the medication as prescribed, even if the effects aren't immediately noticeable.
Can Constella cause weight gain?
Constella (linaclotide) is not known to cause weight gain. The most common side effects are diarrhea, stomach pain, and bloating. If you notice any unusual changes in your weight while taking Constella, it's a good idea to talk to your doctor, as it could be due to other reasons.
Does Constella cause bloating or gas?
Yes, Constella (linaclotide) can cause bloating or gas as a side effect. Some people may experience these symptoms when taking the medication, especially in the beginning. If the bloating or gas becomes severe or bothersome, it’s a good idea to talk to your doctor.
Can Constella help with abdominal pain?
Yes, Constella (linaclotide) can help with abdominal pain, especially for people with irritable bowel syndrome with constipation (IBS-C). It works by reducing pain signals in the gut and improving bowel movements, which can relieve discomfort over time. However, it may take several weeks for the abdominal pain to improve fully.
Does Constella have any impact on mental health or mood?
Constella (linaclotide) is not known to have a direct impact on mental health or mood. Its primary effects are on the digestive system, helping to relieve symptoms like constipation and abdominal discomfort. However, if you notice any changes in your mood or mental health while taking Constella, it's important to speak with your doctor, as these could be related to other factors or conditions.
How does Constella compare to other constipation medications?
Constella (linaclotide) works differently from most other constipation medications. It increases fluid in the intestines and helps stimulate bowel movements. Compared to laxatives like fiber supplements or stool softeners, which mostly add bulk or soften the stool, Constella directly targets the gut to improve movement. It's often used for people with chronic constipation or irritable bowel syndrome with constipation (IBS-C) when other treatments don't work as well. Some people may prefer it because it can relieve both constipation and abdominal discomfort, but its effectiveness and side effects can vary from person to person.
Linzess/Constella (Linaclotide) Coupon
