What is Amitiza used for?

Amitiza (lubiprostone) increases the secretion of fluids into the intestines to make it easier to have bowel movements. Amitiza is prescribed to treat chronic constipation, or constipation caused by opioid pain medication. Amitiza can also be used to treat irritable bowel syndrome in women who have constipation as their main symptom.

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    Frequently Asked Questions About Amitiza

    How to Use Amitiza?

    Take Amitiza exactly as your doctor instructs you. Do not take more or less of it or take it more often or for longer than your doctor ordered. If you do, you can increase the risk of negative side effects.

    Swallow the gelcap whole, do not chew, break, or crush it. Amitiza works best when taken with food and water. Drink at least 6-8 glasses of liquid each day. The glasses should be 8oz each. This will help soften your stool.

    Usually Amitiza is taken twice per day. Follow the directions on your prescription label and ensure you read and follow the medication guide. In order to prevent nausea take Amitiza with food and water.

    Within 1 hour of taking Amitiza you might feel tightness in your chest or shortness of breath. This side effect should go away within 3 hours but might happen again when you take your next dose. If this side effect becomes bothersome call your doctor.

    You may have tightness in your chest or feel short of breath within 1 hour after taking Amitiza. This side effect should go away within 3 hours, but it may occur again when you take your next dose. Talk with your doctor if this side effect becomes bothersome.

    What are side effects of Amitiza?

    Along with the normal effects of Amitiza, it can also cause unwanted side effects. Though not all of these side effects may occur, they may need medical attention if encountered. 

    If the following side effects occur, check in with your doctor immediately: 

    More common

    • Diarrhea
    • Full or bloated feeling or pressure in the stomach
    • Nausea 
    • Stomach pain
    • Swelling of abdominal or stomach area

    Less common

    • Abdominal or stomach discomfort
    • Black, tarry stools
    • Blood in the stools
    • Chest discomfort or pain
    • Chills 
    • Cold or flu-like symptoms
    • Cough 
    • Difficult or labored breathing
    • Fever 
    • General feeling of discomfort or illness
    • Headache 
    • Increased sweating
    • Joint pain
    • Loss of appetite
    • Loss of bowel control
    • Muscle aches and pains
    • Runny nose
    • Shivering 
    • Shortness of breath
    • Sore throat
    • Sweating 
    • Tightness in the chest
    • Trouble sleeping
    • Unusual tiredness or weakness
    • Vomiting 

    Incidence not known

    • Abdominal or stomach tenderness
    • Difficulty with swallowing
    • Fainting 
    • Fast, pounding, or irregular heartbeat or pulse
    • Hives 
    • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    • Skin rash
    • Swelling 

    If any of the following symptoms of Amitiza overdose occur get emergency medical help: 

    Symptoms of overdose

    • Dry heaves
    • Dry mouth
    • Feeling of warmth
    • Lack or loss of strength
    • Paleness of the skin
    • Redness of the face, neck, arms, and occasionally, upper chest
    • Severe, unusual tiredness or weakness
    • Weight loss

    You may experience side effects of Amitiza that don’t need medical attention. These side effects will usually go away as your body adjusts to the medication during treatment. Your health care provider may also be able to tell you some ways to reduce these Amitiza side effects. If the following side effects become bothersome, talk to your healthcare provider: 

    More common

    • Excess air or gas in the stomach or intestines
    • Passing gas

    Less common

    • Acid or sour stomach
    • Belching 
    • Bladder pain
    • Bloody or cloudy urine
    • Change in taste
    • Cold sweats
    • Difficult, burning, or painful urination
    • Difficulty with moving
    • Discouragement 
    • Dizziness 
    • Fear or nervousness
    • Feeling sad or empty
    • Frequent urge to urinate
    • Heartburn 
    • Increased weight
    • Indigestion 
    • Irritability 
    • Loss of interest or pleasure
    • Loss of taste
    • Lower back or side pain
    • Muscle cramps
    • Muscle stiffness
    • Sore throat
    • Stomach upset
    • Swollen joints
    • Tingling of the hands or feet
    • Unusual drowsiness, dullness, tiredness, or feeling of sluggishness

    You may experience side effects of Amitiza not listed here. If you do, contact your doctor right away. If you have questions about side effects you can call us at 1-844-416-4282 and ask to be transferred to a pharmacist for counselling.

    DISCLAIMER: The following information is provided as an educational aid for those looking into Amitiza gelcaps. This is not intended to be used as a replacement for advice from a medical professional. Always seek the advice of a healthcare professional for your medical condition or treatment. Do not ignore or delay seeking professional medical advice because of the information provided here.