What is Tolvaptan used for?
Tolvaptan (Samsca) is a medication that is used to help regulate low sodium levels (salt) in the body. Sodium deficiency can lead to conditions such as hormone imbalance and heart failure.
It works by creating more urine in the body which removes excess water while retaining sodium. This allows for a regular level of sodium in the blood. Tolvaptan is classified as a vasopressin receptor antagonist. It works with the pituitary gland to produce more urine to treat hyponatremia.
Your doctor may have prescribed this to manage other conditions. If you are unsure why you are taking Tolvaptan contact your doctor to clarify how it is meant to benefit you.
Frequently Asked Questions About Tolvaptan
Before you begin taking Tolvaptan, and after every refill, carefully read the medication guide provided with the packaging. If you have any questions, or if the instructions are unclear, call your doctor or pharmacist to provide medical advice. This can be taken with or without food as recommended by your doctor.
You may need to drink more water during treatment. Generally speaking, if you feel thirsty, you likely need to take a drink of water. You should not take this for longer than 30 days unless instructed by your doctor.
Taking Tolvaptan consistently is crucial to receive the most benefit. Do not stop taking tolvaptan unless otherwise instructed by your doctor. Stopping and starting treatment may negate the therapeutic benefit.
If you miss a dose you can take it when you remember. If it is almost time for your next dose, skip the missed dose and continue with your schedule. Inform your doctor to determine if this will affect treatment.
Grapefruit and grapefruit adjacent products can lead to an increased risk of side effects. Avoid these products unless your doctor can advise you how to enjoy them safely.
Tolvaptan may contribute to liver problems such as liver injury, liver disease and liver failure. You may need to be assessed to determine whether or not Tolvaptan will lead to health complications. Store tablets at room temperature out of reach of children and animals.
Tolvaptan has known side effects. This is not a complete list and includes frequently reported adverse events. If you experience any signs and symptoms of serious side effects when taking Tolvaptan, talk to your doctor or seek emergency care.
Report side effects with Tolvaptan to your doctor. If you find them unmanageable call your doctor for medical advice about side effects.
- general feeling of tiredness or weakness
- dizziness or lightheadedness
- Loss of appetite
- bloody stools
- tightness in the chest
- chest pain
- Difficulty having a bowel movement
- pink or red urine
- stomach pain
- hives, itching, skin rash
- coughing or vomiting blood
- high blood pressure
- irregular, fast or slow, or shallow breathing
- yellow eyes or skin
- troubled breathing
- weight loss
- stomach pain, continuing
- Blurred vision
- flushed, dry skin
- rectal bleeding
- unusual tiredness or weakness
- blue lips, fingernails, or skin
- muscle twitching
- swelling of the feet or lower legs
- dry mouth
- fruit-like breath odor
- frequent urination
- fast, slow, irregular, or shallow heartbeat
- increased urination
- increased thirst
- unexplained weight loss
- light-colored stools
- loss of consciousness
- dark urine
- troubled breathing
- lack or loss of strength
- muscle cramp, spasm, pain, or stiffness
- stomach tenderness
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- pain, redness, or swelling in the arm or leg
- increased volume of pale, dilute urine
- blood in the urine
- vaginal bleeding
- increased hunger
- Difficulty swallowing
- persistent bleeding or oozing from puncture sites, mouth, or nose
- vomiting or diarrhea
The following drugs are known to interact with Tolvaptan. This is not an exhaustive list of all possible drug interactions. It is important to disclose all your current medications, (including prescription medications and herbal products) with your doctor to prevent allergic reactions or adverse interactions. They may have to determine if the interaction is worth the benefit of using both drugs or if your therapeutic plan needs to be changed.
- St John's Wort
- Tenofovir Alafenamide
DISCLAIMER: The information provided here is for informational purposes only and is not intended to replace the medical advice provided by a certified medical professional. Any prescription drug use needs to be approved by your doctor. Do not avoid or ignore any advice provided by your physician in favor of what is written here. Always consult with a pharmacist or doctor before taking this medication and seek counselling if you have any questions or concerns about your medication.