What is Sandomigran?
Sandomigran is used to prevent the severity and frequency of vascular migraine headaches including cluster headache. This cannot be used to stop or prevent a Migraine in progress.
Sandomigran works by preventing blood vessels from temporarily changing size. This is the most common cause of migraine attacks. It can only treat vascular headaches caused by changes with blood vessels, it cannot be used to treat tension headaches. Tension headaches are not clearly understood, however they can occur in tandem with vascular migraines as well.
Do not share this medication with friends and family even if they have similar symptoms. This may not be a relevant treatment and may cause adverse reactions. Sandomigran is stored at room temperature, in a dry place out of reach of children and direct sunlight.
Frequently Asked Questions About Sandomigran (Pizotifen)
When talking to your doctor or pharmacist about Sandomigran, they will likely inform you how often and how many should be taken. The manufacturer also provides a drug information pamphlet in their packaging. The dose can vary based on your condition, age, size and response to treatment.
Your doctor will monitor your medical condition to see if your condition improves. They may gradually decrease your dose if treatment looks promising. This is done to avoid “rebound headaches”. These occur when you become too reliant on pain medication.
You should not stop taking this once you feel better. Your doctor will instruct you when and how to decrease your dose and possibly discontinue the medication. You may need to be counselled on the withdrawal symptoms.
If the headaches return after a time, you may need to begin taking Sandomigran at your doctor’s discretion. You need to take Sandomigran consistently, every day, to get the best results. If you forget a dose you can take it once you remember. If it is almost time for your next dose, skip the missed dose and continue with your schedule.
Do not take an extra dose to make up for one you missed. Taking more medication at once will not improve your condition and may lead to more severe or frequent side effects. Check with your doctor if you are concerned about missing doses or taking too much.
Sandomigran has known side effects. This is not a complete list and includes frequently reported adverse events. Call your doctor for medical advice about side effects.
- severe stomach/abdominal pain
- dark urine
- yellowing eyes/skin
- trouble breathing
- mental/mood changes (e.g., confusion, depression, nervousness)
- eye pain
- itching/swelling (especially of the face/tongue/throat)
- decreased sexual ability
- severe dizziness
- persistent nausea/vomiting
- vision changes
- swelling of the ankles/feet
- weight gain
This is not a complete list of all interactions between Sandomigran and other drugs. It is important to disclose all your current medications with your doctor to prevent allergic reactions or adverse interactions. They may have to make a decision if the interaction is worth the benefit of using either drug or if your therapeutic regime needs to be changed.
- monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, rasagiline, phenelzine, selegiline, tranylcypromine)
- barbiturates (e.g., phenobarbital, butalbital)
- tricyclic antidepressants (e.g., amitriptyline, desipramine)
- selective serotonin reuptake inhibitors (SSRIs; e.g., paroxetine, sertraline)
- muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine)
- magnesium sulfate
- botulinum toxin
- potassium supplements
- cholinesterase inhibitors (e.g., donepezil, galantamine, rivastigmine)
- seizure medications (e.g., clobazam, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
- thiazide diuretics (e.g., hydrochlorothiazide, chlorthalidone)
- chloral hydrate
- antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
- sodium oxybate
- amphetamines (e.g., dextroamphetamine, lisdexamfetamine)
- benzodiazepines (e.g., diazepam, lorazepam)
- narcotic pain relievers (e.g., codeine, morphine)
DISCLAIMER: The information provided here is intended to provide basic information on this medication and is not intended to replace the medical advice provided by a certified medical professional. Any prescription drug use needs to be approved by your doctor.
Do not avoid or ignore any advice provided by your physician in favor of what is written here. Always consult with a pharmacist, doctor or health care professional before taking this medication and seek counselling if you have any questions or concerns about your medication.