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What is Prucalopride used for?

Prucalopride is used to treat chronic constipation when conventional laxatives are not able to treat symptoms. It works by increasing the frequency of contractions in the intestines which makes it easier to make bowel movements.
It is often recommended when the cause of the constipation is unknown (Chronic idiopathic constipation or CIC). Do not share Prucalopride with others even if they have similar symptoms. This may not be an effective treatment and may lead to adverse reactions.

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    Frequently Asked Questions About Prucalopride

    How to Use Prucalopride?

    To get the most benefit from Prucalopride, carefully read the drug information leaflet carefully to understand how to take it and what the side effects might be. Call your doctor or pharmacist if you have any additional questions or if you require any medical advice.

    It is taken orally with or without food as often as prescribed by the doctor. You should notice results within 4 days, inform your doctor as you may need a laxative in addition to Prucalopride to get the desired effect.

    Do not take additional medication expecting better results. It will not provide more benefit and can increase the risk of experiencing side effects.

    If you miss a dose you can take it when you remember. If it is almost time for your next dose, skip the missed dose and continue with your schedule.

    What are Side Effects of Prucalopride?

    Prucalopride Has known side effects. This is not a complete list and includes frequently reported adverse events. If you experience any signs and symptoms of serious side effects when taking Prucalopride, talk to your doctor or emergency care.

    Report side effects with Prucalopride to your doctor. If you find them unmanageable call your doctor for medical advice about side effects.

    • passing gas
    • Diarrhea
    • slow speech
    • thoughts or attempts at killing oneself
    • tightness in the chest
    • sweating
    • redness of the skin
    • swelling of the face
    • headache, severe and throbbing
    • pain or discomfort in the arms, jaw, back, or neck
    • double vision
    • Abnormal stomach or bowel sounds
    • Hives or welts, itching, skin rash
    • stomach distension
    • troubled breathing
    • confusion
    • decreased appetite
    • bloated or full feeling
    • difficulty in speaking
    • stomach pain
    • unusual tiredness or weakness
    • inability to move the arms, legs, or facial muscles
    • Chest pain or discomfort
    • headache
    • inability to speak
    • dizziness
    • excess air or gas in the stomach or bowels
    • nausea
    • Frequent urination of small amounts of urine in the daytime
    • suicidal thoughts or mood problems

    Prucalopride Drug Interactions

    The following drugs are known to interact with Prucalopride. This is not an exhaustive list of all possible drug interactions. It is important to disclose all your current medications, (including prescription medications and herbal products) with your doctor to prevent allergic reactions or adverse interactions. They may have to determine if the interaction is worth the benefit of using both drugs or if your therapeutic plan needs to be changed.

    • propafenone
    • cyclosporine
    • daclatasvir
    • progestins (e.g., dienogest, levonorgestrel, medroxyprogesterone, norethindrone)
    • macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
    • quinine
    • dronedarone
    • lapatinib
    • amiodarone
    • digoxin
    • verapamil
    • ivacaftor
    • quinidine
    • birth control pills
    • "azole" antifungals (e.g., itraconazole, ketoconazole, voriconazole)
    • carvedilol
    • estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)

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    DISCLAIMER: The information provided here is for informational purposes only and is not intended to replace the medical advice provided by a certified medical professional. Any prescription drug use needs to be approved by your doctor.
    Do not avoid or ignore any advice provided by your physician in favor of what is written here. Always consult with a pharmacist or doctor before taking this medication and seek counselling if you have any questions or concerns about your medication.