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HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Unless directed by your doctor do not stop taking apixaban. Stopping this medication early increases the risk of forming a serious blood clot. Your doctor may have you take a different “blood thinning” medication to reduce your risk. If you experience weakness on one side of your body, sudden vision changes, chest pain, confusion, trouble speaking, warmth/swelling/pain in the legs get medical help immediately.

After certain spinal procedures people taking this medication may bleed near the spinal cord which can cause paralysis that can last a long time or become permanent. Talk to your doctor about the risks before any spinal procedure. If you have a deformed spine or have had spinal surgery before or are taking other drugs that cause bruising/bleeding the risks of bleeding can be higher. If you notice any symptoms such as leg tingling/numbness/weakness, loss of control of the bladder/bowels, or back pain tell your doctor asap.

Apixaban is used in the prevention of serious blood clots forming due to a particular irregular heartbeat or after knee/hip replacement surgery. Part of the heart with atrial fibrillation does not beat the way it should. This can lead to the formation of blood clots which can travel to other parts of the body or increase your risk of stroke. It is also approved to treat types of blood clots in the US. It is an anticoagulant that blocks certain clotting proteins in your blood.

Take this medication as directed by your doctor generally twice per day. If you’re unable to wholly swallow the tablet crush it and mix with water, apple juice or applesauce and take immediately. Tell your doctor and pharmacist about all medications you’re taking and all of the products you use. Do not stop this medication without consulting your doctor first as abruptly stopping this medication can worsen some conditions. Order refills early to avoid running out of this medication.

Easy bruising, minor bleeding or nausea may occur. If these effects worsen or persist speak with your doctor promptly. Your doctor has assessed the risks and benefits of this medication and has prescribed this medication to you as they believe the benefits outweigh the risks. Most people on this medication do not experience serious side effects.

If this medication affects your blood clotting proteins too much it can cause serious bleeding. If you have signs of serious bleeding including: prolonged bleeding by cuts or gums, persistent/frequent nosebleeds, difficulty swallowing, vomit that is bloody or looks like coffee grounds among others.

If you experience any of these very serious side effects get medical attention immediately: confusion, vision changes, slurred speech, weakness on one side of the body. Serious allergic reactions to this drug are rare, though if you notice the following symptoms seek medical attention immediately: swelling/itching, rash, trouble breathing, or dizziness. This list is not complete, if you notice other side effects talk to your doctor promptly.

Before you take apixaban inform your doctor and pharmacist of all allergies as it may contain inactive ingredients that can lead to allergic reactions or serious problems. Also discuss your medical history especially: kidney disease, bleeding problems, liver disease,blood disorders, frequent falls/injuries, stroke, recent major surgery/injury.

If you are going to have surgery tell your doctor and dentist about all medications you’re taking. Your dentist or doctor may tell you to stop taking apixaban before your surgery, make sure you go over specific instructions. Frequent use of alcohol can increase your risk for internal bleeding so limit alcoholic beverages. Use caution with objects that can injure you to limit injury and bleeding, also avoid activities such as contact sports.

If you fall and injure yourself contact your doctor right away as they may need to check your for serious hidden bleeding. This medication should only be used during pregnancy when clearly needed, and it is unknown if this medication passes into breast milk so talk to your doctor before breast-feeding.

Drug interactions can increase your risk of serious side effects or change how your medications work. This medication doesn’t contain all possible drug interactions so share a list with your pharmacist and doctor of all the products you take. Do not adjust how you take this medication without consulting your doctor. Some medications that interact with this drug include: drugs that can cause bleeding/bruising, mifepristone, some antidepressants.

Other drugs can affect how apixaban is removed from the body which can affect how it works. Examples include: HIV protease inhibitors, conivaptan, azole antifungals, rifamycins, drugs used to treat seizures, St John’s Wort, and others. Check prescription labels carefully since many medicines contain fever reducers/pain relievers that can increase risk of bleeding if taken with this medication.

If your doctor has told you to take a low-dose aspirin to prevent stroke or heart attack continue to take the aspirin unless told otherwise by your doctor.

If someone has passed out or has trouble breathing they may have overdosed and you should contact 911 or poison control immediately.

This medication is not to be shared with others. Medical/laboratory tests can be performed periodically to check for side effects and monitor progress.

If you forget a dose take it when you remember. If it is too close to the time of your next dose skip the missed dose and take your next one at the regular time. Do not double the dose in an attempt to catch up.

Do not store this product in the bathroom, keep it away from moisture and light. Keep all medications safe from pets and children. Only dispose of medications as directed by a pharmacist or waste disposal company.

Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).